Trump's punishing tariffs have shaken a global trading order that has persisted for decades, raised fears of recession and driven worldwide stocks sharply downward.
The S&P 500 has shed nearly $US6 trillion ($A10 trillion) in value since Trump unveiled the tariffs a week ago, the deepest four-day loss since the benchmark's creation in the 1950s. The index is now nearing a bear market, defined as 20 per cent below its most recent high.
A sell-off across Asian markets resumed on Wednesday after a brief respite, with Japan's Nikkei down over 3.0 per cent and South Korea's won currency sliding to a more than 16-year low.
US stock futures also pointed to a fifth consecutive day of losses on Wall Street.
Trump has offered investors mixed signals about whether the tariffs will remain in the long term, describing them as "permanent" but also boasting that they are pressuring other leaders to ask for negotiations.
"We have a lot of countries coming in that want to make deals," he said at a White House event on Tuesday afternoon. He said at a later event that he expected China to pursue an agreement as well.
Trump's administration has scheduled talks with South Korea and Japan, two close allies and major trading partners, and Italian Prime Minister Giorgia Meloni is due to visit next week.
The deputy prime minister of Vietnam, the low-cost Asian manufacturing hub hit with some of the highest duties globally, is set to talk with Trump's Treasury Secretary Scott Bessent later on Wednesday.
The prospect of deals with other countries had pushed stock markets up earlier on Tuesday, but US stocks had ceded their gains by the end of the trading day.
Trump nearly doubled duties on Chinese imports, which had been set at 54 per cent last week, in response to counter-tariffs that Beijing announced last week. China has vowed to fight what it views as blackmail.
Top Chinese brokerages have pledged to work together to help steady domestic share prices in response to the tariff-induced turmoil.
Economists have warned that US consumers are likely to face higher prices on everything from sneakers to wine as a result of the trade war.
The full effects of Wednesday's tariffs may not be felt for some time, as any goods already in transit as of midnight will be exempt from the new levies as long as they arrive in the United States by May 27.
Nearly three-quarters of Americans expect the prices of everyday items to rise in the next six months, a new Reuters/Ipsos poll found.
Trump's earlier across-the-board 10 per cent tariffs on all imports from many countries began on Saturday. The latest round of duties are aimed at countries that are "ripping off" the US, according to Trump.
That list includes many of the United States' closest allies, including the European Union, which was hit with a 20 per cent tariff.
Trump has said the tariffs are a response to barriers put on US goods that have stymied American businesses. He has also accused countries including Japan of devaluing their currencies to gain a trade advantage, something Tokyo denies.
Japan's finance minister on Wednesday said trade negotiations with Washington could include foreign exchange rates.
Trump has signalled he may not be finished on tariffs.
In remarks to Republican lawmakers on Tuesday evening, he said he would soon announce "major" tariffs on pharmaceutical imports, one of a handful of categories of goods that have been exempted from the new taxes.
