There were 756 suicide deaths last year, a nine per cent increase on 2021 numbers, according to the latest coroner's report published on Monday.
It is the highest number of deaths the court has seen since it started recording suicide data in 2000.
More people were taking their lives in the later part of 2022, with about 65 deaths per month between August and December compared to 58 per month earlier in the year.
There was also a spike in people aged 65 and over dying by suicide, a 32 per cent increase on 2021 numbers.
"It is troubling to see an increase in suicides emerge in the last few months of 2022," State Coroner Judge John Cain said in a statement.
"It is not clear what is driving this increase - especially amongst those 65 and over - but we are monitoring closely to see if this trend continues."
In Victoria, all suspected suicides are required to be reported to the coroner for investigation.
Social isolation, mental health issues, substance abuse, familial conflict and financial pressures remain common stressors in cases of suicide.
"Access to support is a vital part of suicide prevention," Judge Cain said. "Suicide is complex and requires a multifaceted approach to minimise harm."
The coroner's court is continuing to investigate the majority of suicides that happened last year.
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