When police went looking for the suspected driver at a house in Craigmore on Saturday night they found two men fighting, with one holding a knife.
A 32-year-old Salisbury North man told officers he'd stabbed himself. The man later died.
Roughly six hours earlier, a pedestrian was struck by a white Toyota four-wheel drive at Andrews Farm following an alleged domestic disturbance.
A 26-year-old man suffered serious but non-life threatening injuries.
Around 9pm police were told the driver involved was at a home in nearby Craigmore.
Two men could be heard arguing inside and a 4WD matching the description of the car involved in the collision was parked in the driveway.
Officers say they found the pair involved in an altercation on the floor and disarmed the 32-year-old, but his condition quickly started to deteriorate.
He was given CPR but died before paramedics arrived.
His death is being treated as a death in custody and will be the subject of a report to the State Coroner.
A 41-year-old man involved suffered wounds to his hands and is being treated in hospital.
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