Record rainfall has lashed central and western Queensland, isolating communities, inundating roads and affecting telecommunications.
The northeast tropical coast has also been hit hard by the wet weather, with no respite in sight.
Heavy falls are expected to move south in coming days, threatening a region that has just recovered from an ex-cyclone's aftermath.
Major flood warnings have been issued across central and western Queensland, along with the Bohle and Haughton rivers near Townsville in the north.
The Townsville region had already been hit hard by February floods triggered by record rainfall that claimed two lives, forced hundreds to evacuate and cut power for days.
A flood watch is also current for systems from the Gulf of Carpentaria down to the Warrego River in the far south.
"This will be a significant, widespread and prolonged flood event across the state," the Bureau of Meteorology's Angus Hines said.
"Even once the rain clears these rivers will stay above their flood levels for several days, if not weeks, and the rain is far from clearing."
The Quilpie community is among a number of regions threatened by floodwaters in central and western Queensland, with more rain expected.
"We're working closely with the state (government) to look at if there's a need to fly in food supplies," Quilpie Council CEO Justin Hancock told AAP.
"It's too early to tell how long we're going to be cut off for to make the call.
"Once the current threats of flooding reduces we have to turn our attention to the recovery efforts, particularly those in our agricultural sector that'll be significantly impacted."
A severe weather warning has been issued for the central west's Winton to Cunnamulla near the NSW border.
In coming days the rain is set to shift south, with a "very wet day" forecast on Saturday for coastal areas from central Queensland's Yeppoon to southern NSW's Bega, including Brisbane and Sydney.
Sandbagging sites began reopening around Brisbane as the southeast braces again after recovering from ex-Tropical Cyclone Alfred just weeks ago.