Bremner made her debut for Australia in 2013 and made a triumphant return to the green-and-gold jersey last year as a mother of two.
The joint leading try-scorer for the Jillaroos, 31-year-old Bremner scored 14 international tries through her career and won two World Cups with Australia.
The fullback also played seven games for NSW, and was the inaugural captain of St George Illawarra's NRLW side.
Bremner's decision means she goes out on top of her game, after being named the Dally M fullback of the year last season in the NRLW.
"I am extremely proud of my career, not for any of the accolades or 'successes' but for the way I did it, in my own way even if it meant taking the path less travelled," Bremner posted on Instagram.
"This game has had a huge influence on who I am and what I value in life, it has helped shape who I am, and what I stand for.Â
"There has been an entire community that has been on this roller coaster with me, from a young teenager to a 31-year-old mum."
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