The 54-year-old filmmaker was known to be working on a mystery project with the likes of Anne Hathaway, Charlize Theron, Matt Damon, Tom Holland, Zendaya, Robert Pattinson, and Lupita Nyong'o for a 2026 release.
Universal have confirmed he is working on The Odyssey, which the studio says will be a mythic action epic shot across the world using brand new IMAX film technology.
"The film brings Homer's foundational saga to IMAX film screens for the first time and opens in theatres everywhere on July 17, 2026," Universal said.
The poem has been adapted multiple times over the years, notably with Ulysses, which starred Kirk Douglas and was released in 1954, while it also inspired the likes of 2000's O Brother, Where Art Thou?
Hathaway recently admitted it "fills [her] with so much joy" to be working with Nolan on his next movie after previously starring in his 2012 movie The Dark Knight Rises and 2014's Interstellar.
"Getting to be invited twice really felt like something, three felt like it would've been greedy, so I never let myself hope that that would happen," she said.
"That it has makes me emotional, to be perfectly honest. It makes me feel like I'm doing something right."
Spider-Man star Holland admitted he was "honoured" to be teaming up with Nolan for his next project, and said it was a "phone call of a lifetime" when he was presented with the opportunity to take part in the forthcoming film.
"All I can say is that I'm incredibly excited," he told Good Morning America.
"And obviously honoured, but that's all I can say because, to be honest, that's all I know."
Asked if Nolan was the type of director Holland would say yes to "sight unseen", he replied: "100 per cent, without a shadow of a doubt".